A working definition of addiction could be, "the continued use of a substance or engagement in a behavior in spite of negative consequences." Some addictions such as opioid misuse or severe alcoholism have an element of what is called "tissue dependency" where a person may need medical assistance to safely wean off of the drug of choice. However, most addictions such as smoking, overeating, gambling and a host of others do not create tissue dependency, although they can and d